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PDBEB Courses 2018/2019 - Oncometabolism: Principles and Applications
March 11 - 15
Coordinator: Paulo Oliveira (pauloliv@ci.uc.pt) & João Ramalho (jramalho@uc.pt)
Oncometabolism: Principles and Applications
Organizers: Paulo J. Oliveira & João Ramalho-Santos (CNC, University of Coimbra)

March 11-15, 2019

Student enrolment: Paulo J. Oliveira (pauloliv@cnc.uc.pt)

Monday, March 11, 2019

9:30 – 10:00: Course introduction and assignments
10:00 – 11:00: John Jones (CNC/University of Coimbra) “What is metabolism?”   
11:00 – 12:00: Carmen Alpoim (CNC/University of Coimbra) “Introduction to Cancer Biology”
14:00 - 15:00: Ana Urbano (DCV/University of Coimbra) “The Warburg effect as the cornerstone of oncometabolism”
15:00: Networking

Tuesday, March 12, 2019

10:00 – 11:00: João Ramalho-Santos (CNC/University of Coimbra) “From StemMetabolism to Oncometabolism, and back again”
11:00-11:30: Ana S. Rodrigues (CNC/University of Coimbra) “Metabolic regulation of pluripotency”
11:30 – 12:30: Sérgio Dias (IMM/University of Lisbon) “Metabolic alterations underlying phenotypic modifications in cancer cells”
14:30-15:30: Valdemar Máximo (I3S/IPATIMUP) “Impact of metabolism in epigenetic remodeling of cancer cells”
15:30: Networking

Wednesday, March 13, 2019

10:00 – 11:00: Célia Gomes (FMUC/University of Coimbra) “Cancer stem cells - Physiology and opportunities”
11:00 – 12:00: Nuno Raimundo (University of Göttingen, Germany) “Rewiring of cancer signaling and metabolism”
14:00 – 15:00: Filomena Botelho (FMUC/University of Coimbra) “PET and oncometabolism”
15:00-15:30: Ricardo Marques (CNC/University of Coimbra) “3D cancer stem cell models and methods to address metabolism”
15:30-16:00: Bárbara Sousa (I3S/IPATIMUP) “P-cadherin breast cancer stem cell marker: an antioxidant for metabolic defects caused by loss of matrix attachment”
16:00: Networking

Thursday, March 14, 2019

10:00 – 11:00: Jose M. Cuezva (Universidad Autónoma de Madrid, Spain) “Mitochondrial oxidative phosphorylation in cancer”
11:00 – 12:00: Nuno Raimundo (University of Göttingen, Germany) “Organelle interplay in cancer
14:00-15:00: Paulo J. Oliveira (CNC/University of Coimbra) “Targeting mitochondria in cancer”
15:00-15:30: Ana R. Coelho (CNC/University of Coimbra) “Horizontal DNA transfer and reactivation of mitochondrial respiration in cancer”
15:30-16:00: Rui Carvalho (DCV/University of Coimbra) “Metabolic profiling of tumor metabolism by Nuclear Magnetic Resonance”
16:00: Networking

Friday, March 15, 2019

10:00 – 13:00: Students presentations
14:00 – 15:00: CNC Seminar: Jose M. Cuezva (Universidad Autónoma de Madrid, Spain) “The ATPase Inhibitory Factor 1: A double-edge sword?”

Dear Students:

For the Course evaluation, we propose you a very challenging task.
In groups of 4 students (defined by draft), you need to create a fictitious business idea focusing on any topic covered in this course (e.g. biomarker discovery, intervention, novel equipment for diagnosis, etc, all focusing in cancer) and defend your proposal in a 10-minute pitch to potential investors. Think Shark Tank CNC-style…
The presentation can be supported by any visual means (e.g. Powerpoint slides, MVP, etc) and must contain the following elements:
a) Problem to be solved
b) Current ideas/competition and limitations
c)  Your idea
d) Why your idea is better it better than the competition
e) Team
f) Funding requested / Predicted sales
g) Milestones of your project / possible exit
h) Closing punch line.

All group members must present and answer to questions.

Some useful links:

Papers for Students
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