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PDBEB Courses 2018/2019 - Fighting infection
March 18 - 22
Coordinator: Nuno Empadinhas (numenius@cnc.uc.pt) & Isaura Simões
Fighting infection PDBEB (18-22 March 2019)

Coordinators: Nuno Empadinhas & Isaura Simões

Ana Maranha (CNC & IIIUC, University of Coimbra) ORCID
António Maio (Centro Hospitalar Cova Da Beira, Covilhã) LINK
Chase Beisel (University of Würzburg, Germany) LINK
Elsa Anes (iMed & FFUL, University of Lisboa) ORCID
Gabriela J. Silva (CNC & FFUC, University of Coimbra) ORCID
Inês Baldeiras (CNC & FMUC, University of Coimbra) ORCID
Isaura Simões (CNC & IIIUC, UC-Biotech) ORCID
John D. Marugg (CNC & IIIUC, University of Coimbra) ORCID
Maria Manuel Silva (CNC & FFUC, University of Coimbra) ORCID
Nuno Empadinhas (CNC & IIIUC, University of Coimbra) ORCID
Olga Borges (CNC & FFUC, University of Coimbra) ORCID
Paula Veríssimo (CNC & FCTUC, University of Coimbra) ORCID
Pedro Madureira (Immunethep, Cantanhede) ORCID
Paulo Empadinhas (ENISA, Heraklion, Greece) LINK
Ricardo Vieira-Pires (CNC & IIIUC, UC-Biotech) ORCID
Rita de Sousa (INSA, National Health Institute, Lisboa) LINK
Sara Monteiro (Converde, Cantanhede) ORCID
Sónia Ferreira (CHBV, Centro Hospitalar do Baixo Vouga, Aveiro) ORCID
Susana Alarico (CNC & IIIUC, University of Coimbra) ORCID

Despite huge biomedical breakthroughs in the 20th century, infectious diseases still remain a leading cause of death today.    In 2017, the World Health Organization analysis of "Global Antimicrobial Resistance" highlighted this as a greatest health threat mankind will face in the coming decades.

Worryingly, escalation in the rate of chronic diseases and aging population are major risk factors for numerous infectious diseases. Without new antimicrobial strategies, last century’s major medical breakthroughs such as surgeries, transplants or chemotherapy will be unthinkable, bringing us back to the “dark ages” of medicine. The “Fighting Infection 2019” course will highlight how antibiotics are becoming obsolete. Invited scientists will discuss topics on bacterial, fungal and parasitic agents of infection, prions, viruses and their vectors, as well as some host responses. Innovative antimicrobial strategies that are in place taking advantage of cutting edge technologies will also be highlighted. We also deemed important to include a topic on cybersecurity threats and to intersect the course’s main topic with risk-management strategies in Healthcare. A representative of ENISA - EU Agency for Network and Information Security will address critical issues on Cyber attacks and eHealth Security.

Awareness on these challenges, and what they mean for our collective future, starts with young researchers being aware, from the start, of these issues when working with patient’s data or samples, what the associated risks (both ethical, legal, and operational) may be, and how to best prepare for them. Students are expected to participate interactively in all classes and complete a final exam on the topics they were exposed to.

Monday 18 – Pathogens and antibiotic resistance
09:30 Introduction to the course (Nuno Empadinhas)
10:00 The (ir)resistible world of antibiotics (Sónia Ferreira)
11:00 Acinetobacter spp.: an old friend, a new enemy (Gabriela Silva)

14:00 Sampling and detection strategies for classical and emerging food-borne pathogens (John D. Marugg)
15:00 Diabetic skin: challenges and possibilities of bacterial interspecies competition (Ana Maranha)

Tuesday 19 – Emerging pathogens
09:30 Molecular Mycobacteriology & the Microbiome: new targets on the horizon (Nuno Empadinhas)
10:30 Nontuberculous mycobacteria: an emerging health problem worldwide (Susana Alarico)
11:30 Exploring innate immunity for host directed therapies for Tuberculosis (Elsa Anes)

14:00 The BEB microbiome (Biobanking) (Susana Alarico & Ana Maranha)

Wednesday 20 (UC-Biotech) - Unconventional strategies
09:30 CRISPR-CAS adaptive immune systems in bacteria (Chase Beisel)
10:30 Understanding Rickettsia-macrophage interactions (Isaura Simões)
11:30 SEMINAR – The CRISPR revolution (Chase Beisel)

14:00 Fighting fungal pathogens (Sara Monteiro)
15:00 Antibody-based therapies for microbial and viral diseases (Ricardo Pires)
16:00 Development of new Immunotherapies to fight threatening bacterial infections (Pedro Madureira)

Thursday 21 - Viruses, prions and vectors

09:30 Overview on human prion diseases: molecular and clinical aspects (Inês Baldeiras)
10:30 Nanoparticles as adjuvants in modern vaccines (Olga Borges)
11:30 Emerging challenges on vector-borne diseases (Rita de Sousa)

14:30 Challenges of virology in the 21st century (António Maio)
15:30 Social program

Friday 22 – Host responses, medicinal chemistry and cyber threats

09:30 Allergies and allergic inflammation (Paula Veríssimo)
10:30 A Medicinal chemistry perspective on antimalarials (Maria Manuel Silva)

14:00 SEMINAR - Cybersecurity risks and threats in the health sector (Paulo Empadinhas)
15:00 Evaluation test & perspectives
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